Conference Proceedings
Retinal ganglion cells electrophysiology: the effect of cell morphology on impulse waveform
MI Maturana, R Wong, SL Cloherty, MR Ibbotson, AE Hadjinicolaou, DB Grayden, AN Burkitt, H Meffin, BJ O'Brien, T Kameneva
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference | IEEE | Published : 2013
Abstract
There are 16 morphologically defined classes of rats retinal ganglion cells (RGCs). Using computer simulation of a realistic anatomically correct A1 mouse RGC, we investigate the effect of the cell's morphology on its impulse waveform, using the first-, and second-order time derivatives as well as the phase plot features. Using whole cell patch clamp recordings, we recorded the impulse waveform for each of the rat RGCs types. While we found some clear differences in many features of the impulse waveforms for A2 and B2 cells compared to other cell classes, many cell types did not show clear differences.
Related Projects (2)
Grants
Awarded by NHMRC
Awarded by ARC Discovery
Funding Acknowledgements
The authors wish to thank Emily O'Brien for her help classifying A1 mice RGC cell for simulations. This research was supported by the Australian Research Council (ARC) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. This research was supported by NHMRC Project grant 585440 and ARC Discovery grant DP0881247.